Obesity paradox in chronic heart failure with moderately reduced or preserved left ventricular ejection fraction: impact on a prognosis for patients according to a five-year follow-up

Aim. To investigate the obesity paradox by studying impact of overweight and abdominal on prognosis in chronic heart failure (CHF) patients with moderately reduced or preserved left ventricular ejection fraction (LVEF) five-year follow-up results. Materials methods. A prospective, open, parallel-group study included 314 CHF LVEF, average age was 65.3 ± 11.2 years. Group 1 – 66 normal weight; 2 67 patients; 3 90 I degree obesity; 4 91 subjects II–III degrees obesity. Adverse cardiovascular events (CVEs) were studied as a cumulative endpoint, death, rehospitalization due to decompensated CHF. Results. It has been found that excess body weight (overweight I–III obesity) did not affect prevalence spectrum adverse CVEs LVEF. In patients, compared group, incidence end point (by 15.4 %; χ2 = 3.95, p < 0.05) cases re-hospitalization 19.0 5.6, more often observed. Concomitant associated an increased risk for faster onset (HR 1.46, 95 % CI 1.1–2.2, 1.53, 1.1–2.4, 0.05). Conclusions. The presence LVEF during follow-up. overweight, comparison obesity, disease decompensation observed, which could be evidence existence paradox. most effect caused concomitant which, there significant increase disease.